By National Council on Radiation Protection and Measurements
Read Online or Download Tritium and other radionuclide labeled organic compounds incorporated in genetic material: Recommendations of the National Council on Radiation Protection and Measurements (NCRP report ; no. 63) PDF
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Extra info for Tritium and other radionuclide labeled organic compounds incorporated in genetic material: Recommendations of the National Council on Radiation Protection and Measurements (NCRP report ; no. 63)
SUMMARY nucleic acid precursors in the average labeled bone marrow cells were taken to apply to the average stem cell. The amounts of labeled nucleic acid precursor administered at one time or continuously by different routes that would deliver 5 rem per year to the average labeled hematopoietic and spermatogonial stem cell nucleus were calculated and the results are listed in Table 2, the Summary Table. TABLE 2-Summary table Amount of labeled compounds that delivers 5 rad per year to hemopoietic and spermatogonial stem cell nuclei.
Hence, the ratio of radiation doses in the cell nuclei after oral ingestion and intravenous injection of the same amount of 3H-thymidine is 1:5. Dose to Stem Cells a n d Bone Marrow. 1). 1 pCi per g body weight. 6 times more hazardous than 3H ingested in water. This recommendation may require modification as more precise data on stem cells and on the distribution and rate of incorporation of ingested 3H-thymidine in man become available. 3 Continuous Intake of Tritiated Thymidine When tritiated thyrnidine is continuously consumed or administered, it labels cells as they progressively come into DNA synthesis.
During continuous administration of 3H-thymidine, the labeling intensity of the ceU is halved a t mitosis. 5 times the preceding intensity. 75 the initial value. It is easily seen that, upon continuous exposure to the precursor a t a constant level, the average labeling intensity of the diploid cells will converge to unity with time and the average labeling intensity of tetraploid cells will converge to twice unity. In other words, the cells in S phase will have labeling intensities varying between 1 and 2 of the initial intensity after equilibrium is reached.