Download Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant PDF

By David A. Gewirtz, Shawn E. Holt, Steven Grant

This e-book offers perception into demonstrated practices and learn into apoptosis and senescence. the amount completely examines novel and rising ideas and learn within the fields of phone dying pathways, senescence progress arrest, medications and resistance, DNA harm reaction, and different themes that also carry mysteries for researchers. In overall, this quantity presents easy scientists and clinicians with a deeper and extra entire figuring out of the mobile responses of malignancies which can make certain the effectiveness of remedy, either within the preliminary levels of the affliction in addition to in affliction recurrence.

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Additional info for Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

Sample text

274. Theodorakis P, Lomonosova E, Chinnadurai G. Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells. Cancer Res 2002; 62:3373–6. 275. Yamaguchi H, Bhalla K, Wang HG. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Cancer Res 2003; 3(7):1483–9. 276. Matikainen T, Perez GI, Jurisicova A, et al. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.

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279. Hu Y, Cherton-Horvat G, Dragowska V, et al. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003; 9(7):2826–36. 280. Soengas MS, Capodieci P, Polsky D, et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001; 409(6817):207–11. 281. Yoshida H, Kong Y-Y, Yoshida R, et al. Apaf1 Is required for mitochondrial pathways of apoptosis and brain development.

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