By Daniel M. Albert MD MS, Joan W. Miller MD, Dimitri T. Azar MD, Barbara A. Blodi MD
Contained in the third variation of this esteemed masterwork, 1000s of the main individual professionals from worldwide offer latest top solutions to each query that arises on your perform. They convey in-depth advice on new diagnostic methods, operative method, and therapy alternative, in addition to cogent causes of each new medical thought and its scientific value. With its new streamlined, extra easy, full-color structure - in addition to entry to the full contents on-line - this third version makes reference a lot swifter, more uncomplicated, and extra flexible. greater than ever, it is the resource you want to successfully and expectantly conquer any medical problem you could face.Comprehensive, authoritative, and richly illustrated insurance of each clinical and medical precept in ophthalmology guarantees that you'll consistently manage to locate the counsel you must diagnose and deal with your sufferers' ocular difficulties and meet contemporary criteria of care.Updates comprise thoroughly new sections on "Refractive surgical procedure" and "Ethics and Professionalism"... an up-to-date and increased "Geneitcs" section... an up to date "Retina" part that includes OCT imaging and new drug cures for macular degeneration... and lots of different vital new advancements that have an effect on your sufferer care.A streamlined layout (now 4 volumes rather than six) and a brand new, extra basic full-color layout - with many at-a-glance precis tables, algorithms, bins, diagrams, and hundreds of thousands of exceptional colour illustrations - permits you to find the help you would like extra speedily than ever. entry to the entire contents of the four-volume set on-line - with fast seek features and downloadable illustrations - allows you to speedy and powerfully reference the fabric from any computer.Your buy entitles you to entry the website until eventually the following variation is released, or till the present version isn't any longer provided on the market by way of Elsevier, whichever happens first. If the following variation is released under 365 days after your buy, you may be entitled to on-line entry for 12 months out of your date of buy. Elsevier reserves the precise to provide an appropriate alternative product (such as a downloadable or CD-ROM-based digital model) should still entry to the website be discontinued.
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Extra resources for Albert & Jakobiec’s Principles & Practice of Ophthalmology, Volume 1
N Engl J Med 1984; 310:550-553. 18. Knudson Jr AG: Genetics of human cancer. Annu Rev Genet 1986; 20:231-251. 19. Herskowitz I: Functional inactivation of genes by dominant negative mutations [review]. Nature 1987; 329:219-322. 20. Moller HU: Inter-familial variability and intra-familial similarities of granular corneal dystrophy Groenouw type I with respect to biomicroscopical appearance and symptomatology. Act Ophthalmol 1989; 67:669-677. 21. Klintworth GK: Lattice corneal dystrophy: an inherited variety of amyloidosis restricted to the cornea.
To detect a specific DNA sequence variation, two TaqMan probes are developed, one for each allele, with reporters that fluoresce as different colors. An advantage of this approach is that it is a closed system without the need for purification or electrophoresis of the amplification products, thus reducing the opportunity for sample mix-up and contamination. The procedure also allows for relatively high throughput as 96 samples can be analyzed in a single assay and two to three assays can be run each day.
During cell division, mitochondria and other cytoplasmic organelles are arbitrarily distributed to the daughter cells. Because each cell contains a population of mitochondrial DNA molecules, a single cell can contain DNA molecules that are normal as well as DNA molecules that are mutant (Fig. 6). This heterogeneity of DNA composition, called heteroplasmy, is an important cause of variable expression in mitochondrial diseases. As the diseased mitochondria are distributed to developing tissues, some tissues accumulate more abnormal mitochondria than others.